MedImmune Associate Scientist II/Scientist I - Immuno-oncology, Adoptive Cell Therapy - (Gaithersburg, MD) in Gaithersburg, Maryland

If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions -- join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As an Associate Scientist II/Scientist I in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.

We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

You will conduct and plan preclinical research to discover and develop adoptive cell therapies, including natural cytotoxic T cell therapies, CAR-T, and TCR-engineered T cells targeting tumor-associated antigens and neoantigens, and work closely with a broader team of scientists pursuing adoptive cell therapy. Your focus will be on optimizing several components of therapeutics, including CAR-T and TCR-T function, T cell composition, and advancing new ACT targets, including neoantigens and tumor-associated antigens, and you will work will emphasize CAR-T and TCR-T characterization in tumor models

Essential Requirements

  • Associate scientist II:BS in biology/life sciences or related field and five to eight years of experience in immuno-oncology or related field, or MS in biology/life sciences or related field and three to five years of experience in immuno-oncology or related field

  • Scientist I: Ph.D. in immuno-oncology or related field and two to five years of experience in immuno-oncology or related field

  • Experienced with tumor models (IP, IV, injections, dTGI,immunophenotyping, in vivo pharmacology)

  • Experience in culture, expansion, phenotyping and manipulation of T cells

  • Mastery of multi-color flow cytometry and flow data analysis programs

  • Functional analysis of T cells via quantitation of activation markers, cytokine release and proliferation

  • T cell cytotoxicity assays

Desirable Requirements

  • Lentivirus assembly, tittering, and transduction

  • Molecular and cell biology skills: PCR technologies and genetic manipulation such as Taqman analysis of gene expression, ELISA, shRNA knockdowns, mammalian cell transfection, western blotting, tumor cell culture

  • Strong interpersonal, influencing and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts.

  • Highly organized and able to work independently and in a team environment

  • Self-driven, attention to detail

  • Ability to identify priorities

  • Ability to present results at meetings

  • Outstanding verbal and written communication abilities

Next Steps -- Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience -- it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.