Pfizer Senior Associate Scientist, Ligand Binding Assays in Andover, Massachusetts

  • Laboratory focused position Design, develop and implement ligand binding assays (e.g. ELISA, ECL detection) in biological matrix (plasma, serum) to measure compound concentration, detect the presence of anti-drug antibody and neutralizing anti-product antibody activity in a regulated (GLP, GCP) environment

  • Participate in the design, development and implementation of cell-based assay

  • Perform data analysis and interpretation and be able to draw conclusions regarding progress and results of work, utilizing the data in appropriate decision making

  • Gathers input from colleagues, literature, and additional resources to assist in driving the project forward

  • Knowledge and hands-on experience developing ligand binding assays, utilizing various platforms.

  • Work under supervision of Senior Scientist; some degree of independence, responsible for development of robust and reliable ligand binding in biological matrix (plasma, serum) and /or cell-based assays suitable for characterizing the disposition and immunogenicity of biotherapeutics in various matrixes using a range of potential screening platforms and assay techniques.

  • With some degree of independence, responsible for the design, trouble shooting, validation and conduct of the assay to support biotherapeutic programs.

  • Timely delivery of concentration and immunogenicity data to PDM BioTX principal investigators and other partners in compliance with local or global regulatory requirement.

  • Advancing bioanalytical capabilities to improve efficiency, cost effectiveness and appropriateness of assay for regulated support.

  • With some degree of independence, responsible for development and validation of assays to be governed per departmental SOP.

  • Accurate execution and documentation of bioanalytical method in a regulatory compliant manner.

  • Ensure GLP compliance is maintained in laboratory during study support


  • BSc with at least 5+ years relevant GLP/GCP laboratory experience, with a focus on ligand binding assay development in biological matrix (plasma, serum) and/or cell-based assay experience; MSc with at least 3+ years relevant GLP/GCP laboratory experience with a focus on ligand binding assay development in biological matrix (plasma, serum), cell-based assay experience.

  • Industry experience with a focus in biotherapeutics and a strong record of scientific achievement; excellent communication skills.

  • Proven track record in the area of biotherapeutics bioanalysis with understanding of a broad range of bioanalytical platforms.

  • Skills in GLP/GCP compliant analysis including following SOP and provision of quality regulatory documents.

  • Excellent communication and presentation skills

Technical Skill Requirements

  • Knowledge and hands-on experience developing ligand binding assays, utilizing various platforms.

  • Knowledge and hands on experience working under GLP/GCP regulations

  • Knowledge and experience working with mammalian cells is a plus

  • Broad understanding and skill in areas of bioanalytical laboratory techniques for biotherapeutics.

  • Proven experience generating analytical data in a regulated environment

  • Proven analytical problem solving skill.

  • Proven ability to generate high quality data against challenging time lines

  • Ability to communicate across site and discipline to enable maximum impact of bioanalytical science.

  • Knowledge of biotherapeutic structure, pharmacology, disposition and immunogenicity and the impact on assay selection.

  • Ability to author technical documents, e.g. SOPs, data Summary Reports and Bioanalytical procedures

Behavioral Competencies

  • Adaptability to changing work assignments and priorities

  • Collaborative skills and effective partnering skills in a complex, multi-discipline organizational model

  • Excellent teamwork

  • Interpersonal and communication skills

  • Able to identify opportunities for continuous improvements and enable implementation

  • Ability to work across a matrix team

EEO Statement

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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Additional Details:

  • Last Date to Apply for Job: August 14, 2017

  • Grade: 04

  • Additional Location Information : Andover, MA

  • Eligible for Employee Referral Bonus

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.